Creatine

What Is Creatine?
Creatine is a naturally occurring compound in the body that plays a key role in energy metabolism. It is made in the liver and kidneys from amino acids, then stored mainly in muscles, where it helps regenerate ATP (the body’s short-term energy currency). This process fuels short, high-intensity bursts of activity like sprinting, weightlifting, or jumping.
About 95% of creatine in the body is stored in skeletal muscle. Supplementation increases these stores, supporting both performance and recovery.
Reference: https://pmc.ncbi.nlm.nih.gov/articles/PMC5469049/
​
What Does Creatine Do?
-
Improves performance & power: Boosts capacity for short, high-intensity efforts like lifting or sprinting.
-
Supports muscle & strength gains: Enhances the benefits of resistance training over time.
-
Aids recovery: May reduce fatigue, muscle damage, and support training tolerance.
-
Cognitive benefits: Research suggests possible improvements in memory, focus, and protection against fatigue-related decline.
-
Clinical potential: Being studied for healthy aging, neuroprotection, and metabolic health.
​
Reference: https://jissn.biomedcentral.com/articles/10.1186/s12970-017-0173-z
​
Who Should Use Creatine?
Creatine is most beneficial for:
-
Athletes in strength, sprint, or team sports.
-
Anyone aiming to build muscle and strength.
-
Older adults seeking to maintain muscle mass and function.
-
Vegetarians and vegans (lower dietary intake).
-
Those exploring potential brain or neurological support.
Note: People with kidney conditions, children, or pregnant women should consult a healthcare professional before use.
​
Why Creatine Is the Most Studied Supplement
Creatine monohydrate is considered the most extensively researched performance-enhancing supplement. The International Society of Sports Nutrition calls it the most effective supplement for improving high-intensity exercise and lean muscle growth.
ISSN Position Stand: https://pmc.ncbi.nlm.nih.gov/articles/PMC5469049/
​
Key Clinical / Human Studies & Reviews
-
Safety and efficacy of creatine supplementation in exercise, sport, and medicine (PMC): https://pmc.ncbi.nlm.nih.gov/articles/PMC5469049/
-
Creatine in Health and Disease (PMC): https://pmc.ncbi.nlm.nih.gov/articles/PMC7910963/
-
Common questions and misconceptions about creatine supplementation (PMC): https://pmc.ncbi.nlm.nih.gov/articles/PMC7871530/
-
Creatine supplementation and cognitive function (PubMed): https://pubmed.ncbi.nlm.nih.gov/39070254/
-
Effects of creatine plus resistance training on muscle and performance (PubMed): https://pubmed.ncbi.nlm.nih.gov/37432300/